Course Solutions Uncategorized (Solved) : Investigate Antibody Igg Adnectin Affinitets Dota Chelator Normal Tissue Elisa Technique A Q32603786 . . . .

(Solved) : Investigate Antibody Igg Adnectin Affinitets Dota Chelator Normal Tissue Elisa Technique A Q32603786 . . . .

 

You have to investigate the antibody igG-adnectinaffinitets of DOTA – chelator and normal tissue by ELISA technique,And Aggregeringspropensitet by Lightscattering.  Describe how and by?

You have developed a monoclonal IgG antibody for thecancer-related protein CAIX with the long-term aim of developing anagent for in vivo diagnostics (so-called molecular imaging) ofprostate cancer by PET imaging. However, in previous studies it wasdemonstrated that the long circulation time of the large antibodyin blood resulted in poor contrast between the tumor and the normaltissues. You will therefore try a so-called pre-targeting approach,in which you have genetically fused an Adnectin to the C-terminalof the heavy chain on

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